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Published on: May 31, 2020
The Comparative Effectiveness of Vector Control Approaches for Dengue: A Systematic Review and Multilevel Network
Gary K K Low1,2, Yuling Ke1, Emmanuel Samson3
1Faculty of Medicine and Health, University of Sydney, New South Wales, Australia.
Tropical Medicine & International Health : TM & IH
|August 8, 2026
Summary
Integrated dengue vector control strategies are more effective than standalone methods. This network meta-analysis compared various interventions, finding combined approaches superior for dengue prevention.
Area of Science:
- Public Health
- Infectious Disease Epidemiology
- Vector-Borne Diseases
Background:
- Dengue vector control is crucial for reducing disease burden.
- Conventional meta-analyses have limitations in comparing diverse interventions.
- Network meta-analysis allows for direct and indirect comparisons of multiple interventions.
Purpose of the Study:
- To compare the effectiveness of all dengue vector control interventions.
- To utilize a multilevel Bayesian network meta-analysis for comprehensive comparison.
- To identify optimal strategies for dengue prevention.
Main Methods:
- Included cluster randomized controlled trials (cRCTs) and randomized controlled trials (RCTs).
- Two independent reviewers screened studies, with a third resolving disagreements.
- Assessed entomological indices and epidemiological measures using the Cochrane risk of bias tool.
Main Results:
- Included 48 cRCTs and 13 RCTs; most studies had a high risk of bias.
- Network meta-analyses indicated no significant superiority of most individual interventions.
- Standalone interventions were less effective than combined interventions.
Conclusions:
- Combined dengue vector control interventions are more effective than standalone methods.
- Promoting integrated, multi-faceted vector control strategies is essential for dengue prevention.
- Despite a lack of statistically significant differences between most individual interventions, combination is key.
