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Catalytic Amidation of Carboxylic Acids Using ortho-Aminophenylboronic Acids
Veera K Bruce-Salmenkivi1, Mikko Passiniemi2, Petri M Pihko1
1Department of Chemistry and NanoScience Center, University of Jyväskylä, P.O. Box 35, Jyväskylä FI-40014, Finland.
Abstract:
ortho-Substituted boronic acids have demonstrated significant potential as catalysts for direct amidation reactions, providing a sustainable alternative to conventional coupling reagents. We report the screening of ortho-functionalized arylboronic acids, including four literature benchmarks, as catalysts for the direct condensation of amines and carboxylic acids. The commercially available ortho-aminophenylboronic acids, specifically (2-(piperidin-1-yl)-phenyl)-boronic acid (2-PPBA), emerge as the optimal catalyst, providing amides from a range of carboxylic acids and amines.
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