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Updated: Aug 10, 2026
06:40
In Vivo Imaging of Reactive Oxygen Species in a Murine Wound Model
Published on: November 17, 2018
Fe-MOF@Quercetin complex with light-controlled redox modulation for tumor wound repair
Yuze Xu1,2,3,4, Lan Chang1,2,3,5, Zhaowenbin Zhang1,2,3,4
1State Key Laboratory of Advanced Fiber Materials, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China.
Materials Today. Bio
|August 8, 2026
Summary
This study introduces a novel material (MIL-101-(Fe)@Quercetin) that uses light to control reactive oxygen species (ROS) for melanoma treatment. It effectively inhibits tumor recurrence and promotes wound healing by balancing ROS levels.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Photodynamic Therapy
Background:
- Melanoma excision sites face challenges with tumor recurrence and poor healing.
- Photodynamic therapy (PDT) requires high reactive oxygen species (ROS) to inhibit tumor recurrence but low ROS for wound healing, creating a clinical dilemma.
Purpose of the Study:
- To develop a light-controlled redox-regulating material for balancing ROS generation in melanoma wound sites.
- To address the conflicting ROS requirements for tumor inhibition and wound healing.
Main Methods:
- Synthesis of a MIL-101-(Fe)@Quercetin (MQ) complex material with oxygen vacancies and a narrow bandgap.
- Utilizing laser irradiation to induce ROS generation via efficient electron-hole pair separation in MQ.
- Employing MQ Microneedles (MQ@MNs) for localized delivery and light-controlled ROS modulation in a mouse melanoma wound model.
Main Results:
- MQ demonstrated efficient light-controlled ROS generation and scavenging capabilities.
- MQ@MNs effectively inhibited melanoma tumor growth by releasing ROS in the tumor area.
- MQ@MNs promoted skin wound healing by scavenging excess ROS and enhancing angiogenesis in the wound area.
Conclusions:
- The developed MQ material offers a novel strategy for light-controlled redox regulation of ROS.
- This approach successfully balances the dual requirements of inhibiting melanoma recurrence and promoting wound healing.
- MQ@MNs show significant potential for treating melanoma-associated wounds.
