Related Experiment Video
Updated: Aug 10, 2026
11:47
Heterotopic Renal Autotransplantation in a Porcine Model: A Step-by-Step Protocol
Published on: February 21, 2016
Long Term Outcomes in Living Kidney Donors Over 30 Years
Joana Krättli1, Deborah Buess1, Marie Flohr1
1Swiss Organ Living-Donor Health Registry (SOL-DHR), University Hospital Basel, Basel, Switzerland.
Kidney International Reports
|August 8, 2026
Summary
Living kidney donation is generally safe, with stable kidney function observed long-term. However, factors like male sex, age, and obesity may increase risks, highlighting the need for ongoing donor monitoring.
Area of Science:
- Nephrology
- Transplant Surgery
- Public Health
Background:
- Living kidney donation offers significant benefits to recipients.
- Long-term safety and health outcomes for living kidney donors are crucial considerations.
Purpose of the Study:
- To evaluate the long-term safety and kidney function trajectories of living kidney donors.
- To identify risk factors associated with adverse outcomes in living kidney donors.
Main Methods:
- Prospective, multicenter cohort study of 1863 living kidney donors with ≥ 5 years follow-up.
- Analysis of kidney function using linear mixed-effects models.
- Assessment of a composite endpoint including death, kidney failure, low eGFR, or proteinuria.
Main Results:
- Kidney function remained stable, with a slight average annual increase in eGFR (+0.14 ml/min/1.73 m²).
- Obese and hypertensive donors showed attenuated kidney function slopes.
- Adverse outcomes were rare; 0.2% progressed to dialysis-dependent kidney failure.
Conclusions:
- Living kidney donation demonstrates long-term safety.
- Standardized long-term surveillance is essential for optimizing donor care and counseling.
- Predonation hypertension, obesity, male sex, and older age are independent predictors of adverse outcomes.
Related Concept Videos
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
01:26Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
01:16Kidney Transplant III: Nursing Management
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
01:29Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...