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Diagnostic and management guidelines for biliary atresia in 2025
Liang Ge1, Jixin Yang2, Tengfei Li1
1Department of General Surgery, Tianjin Children's Hospital, Tianjin, China.
Hepatobiliary Surgery and Nutrition
|August 8, 2026
Summary
This guideline offers expert opinions on biliary atresia (BA), a serious infant liver bile duct obstruction. It covers screening, diagnosis, treatment, and follow-up to improve clinical practice for BA patients.
Area of Science:
- Pediatric Hepatology
- Gastroenterology
- Clinical Practice Guidelines
Background:
- Biliary atresia (BA) is a severe pediatric liver disease causing progressive bile duct obstruction and fibrosis.
- Despite recent management advancements, significant challenges persist in treating BA.
- This guideline aims to standardize clinical practice for BA.
Purpose of the Study:
- To provide expert consensus on the screening, diagnosis, treatment, and follow-up of biliary atresia.
- To guide healthcare professionals in managing BA patients effectively.
- To address remaining challenges in BA care.
Main Methods:
- Formulation of clinical questions and recommendations by guideline groups.
- Utilized GRADE Grid, nominal group technique (NGT), and Delphi voting.
- Conducted multiple expert meetings for consensus development.
Main Results:
- Summarized high-quality literature on BA screening, diagnosis, treatment, and follow-up.
- Developed 23 consensus observations with strength of recommendations.
- Incorporated expert opinions from international specialists.
Conclusions:
- International guidelines for BA can inform diverse stakeholders.
- Diagnosis and treatment of BA remain areas of international controversy.
- Further research is needed to advance BA management.
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