Related Experiment Videos
The Evolving Landscape of Gout in the Female: A Narrative Review
Jennifer Lee1, Nicholas Sumpter2, Tony R Merriman2,3
1Department of Internal Medicine, Division of Rheumatology, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Abstract:
Gout is at least three times more prevalent in males than in females. However, concurrent with rising total gout prevalence, complex factors, including comorbidities, diet, lifestyle, and aging, have promoted higher gout prevalence in females. This narrative review focuses on summarizing recent developments in the landscape of gout in females and the mechanisms involved. New knowledge on sex hormone effects on both urate-excreting and urate-reabsorbing transporters and higher hypertension and chronic kidney disease prevalence in females compared to males may help explain why gout incidence rises robustly after menopause in females, to approach that in males. Racial and ethnic factors, risk profiles based on heritable genetic polymorphisms of urate transporters, diet, body mass index, and lifestyle factors differ according to sex. In addition, sex differences in clinical phenotypes, outcomes of gout, and non-gout illnesses include more frequent comorbidities, more pain and disability during gout flares, different perceptions of disease burden, and more frequent severe cutaneous hypersensitivity reaction to allopurinol in females. Collectively, such findings support the potential clinical benefits of tailoring gout and hyperuricemia treatment according to sex.
Related Concept Videos
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Nursing Assessment of the Genitourinary System I: Health History
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Disorders of the Female Reproductive System
Urinary Tract Calculi III: Medical Management
Urinary Tract Calculi V: Nursing Management