Related Experiment Video
Updated: Aug 10, 2026
07:35
A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
Published on: October 13, 2023
Natural language processing to develop a standardized lexicon for precision medicine in oncology
Tianyi Wang1, Kimberly Tsai2, Steven S Kheloussi3
1Omnicom Health Market Access, New York, NY.
Journal of Managed Care & Specialty Pharmacy
|August 8, 2026
Summary
Precision medicine terminology is often inconsistent, causing confusion for stakeholders. A new lexicon was developed to clarify terms and improve understanding for better patient access to precision oncology testing and treatment.
Area of Science:
- Biomedical Sciences
- Health Policy
- Oncology
Background:
- Precision medicine terminology is used inconsistently across clinical, laboratory, payer, regulatory, and policy settings.
- This inconsistency can lead to confusion among multidisciplinary stakeholders with varying expertise.
- Misalignment in understanding precision medicine concepts may impact patient access to testing and treatment.
Purpose of the Study:
- To develop a consolidated lexicon of commonly used precision medicine terms.
- To support clearer communication and foundational understanding across stakeholders in precision medicine.
- To clarify distinctions between related precision medicine concepts for managed care stakeholders.
Main Methods:
- A 2-day partnership forum was held to discuss advancing precision medicine in oncology.
- A comprehensive literature review identified precision medicine terminology sources.
- Natural language processing (NLP) and expert review were used to generate and refine 19 definitions.
Main Results:
- A lexicon of 19 definitions for precision medicine terms was generated.
- Definitions cover foundational concepts, biological underpinnings, biomarker testing, and regulatory aspects.
- The lexicon provides a single reference framework for managed care stakeholders.
Conclusions:
- A standardized lexicon is crucial for consistent understanding of precision medicine terminology.
- Clearer terminology facilitates navigation of guidelines and coverage policies.
- Improved understanding can enhance patient access to precision oncology care.
Related Concept Videos
02:50Combination Therapies and Personalized Medicine
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
02:50Combination Therapies and Personalized Medicine
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:18Cancer
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
01:11Genetic Lingo
Overview