Related Experiment Video
Updated: Aug 10, 2026

Chronic Ovine Model of Right Ventricular Failure and Functional Tricuspid Regurgitation
Published on: March 17, 2023
Novel Caval Valve Implantation in a Patient With Symptomatic Tricuspid Regurgitation and Right Heart Failure
Jessica K Henes1, Andreas Goldschmied1, Isabela Kast1
1Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany.
Background:
Tricuspid regurgitation (TR) is crucial for recurrent cardiac decompensation. Heterotopic transcatheter approaches enable symptomatic treatment of TR in patients who are ineligible for surgery or transcatheter edge-to-edge repair. The TRICENTO G2 prosthesis is a transcatheter bicaval valved stent graft, not yet approved for the market.
First-In-Human/Early Reports Summary:
To the best of our knowledge, this is the first published case of successful TRICENTO G2 transcatheter heart valve implantation, performed as compassionate use in an 81-year-old man with symptomatic TR following multiple interventions. No major complications occurred during the procedure, and a short-term functional improvement in right ventricular function resulted. Given intermittent third-degree atrioventricular block, leadless pacemaker implantation was conducted subsequently.
Discussion:
The TRICENTO G2 represents a promising treatment option for symptomatic TR. However, wise patient selection and vigilant postprocedural observation are essential.
Novelty:
The implementation of the TRICENTO G2 may expand our interventional armamentarium for treating TR.
Take-Home Message:
The TRICENTO G2 may improve tailored treatment of patients with symptomatic TR and right ventricular dysfunction who are ineligible for approved interventions.
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Mitral Regurgitation I: Introduction
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Cardiac Catheterization II: Right Heart Catheterization
Mitral Regurgitation III: Medical Management
Aortic Regurgitation III: Medical Management
Mitral Regurgitation IV: Nursing Management