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Abietane-Type Diterpenoids From Salvia kiangsiensis: Isolation, Semisynthesis, and Cytotoxicity of Their Oxime Ester
Wei-Ye Wu1,2, Lei-Ming Wu2, Lu Gan2
1Key Lab of Natural Product Chemistry and Application at Universities of Education Department of Xinjiang Uygur Autonomous Region, School of Chemistry and Chemical Engineering, Yili Normal University, Yining, China.
Abstract:
Systematic phytochemical investigation of whole plant of Salvia kiangsiensis led to the isolation of three undescribed abietane diterpenoids (1-3) and 24 known analogues (4-27), while compounds 2 and 3 belong to the 20-norabietane skeleton. Four derivatives (24a-24d) were also obtained through structural optimization. Their structures were elucidated by a combination of spectroscopic data, chemical methods, and x-ray diffraction. Cytotoxicity screening indicated that 24c, an oxime ester derivative of 24, exerted the most potent activity against the non-small-cell lung cancer (NSCLC) cell line H1975, with higher potency than the positive control cisplatin. Mechanism study revealed that 24c could promote cell-cycle arrest in S phase and induce cell apoptosis.
