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An Injury-Conforming Dual-Layer Lung Sealant
Shadi Sarami1, Mohammad Mir1, Yuvaraj Manchukan1
1Department of Biomedical Engineering, Stevens Institute of Technology, Hoboken, New Jersey07030, United States.
ACS Biomaterials Science & Engineering
|August 8, 2026
Summary
A novel dual-layer sealant effectively seals persistent pulmonary air leaks. This injury-conforming sealant maintains lung function during ventilation, improving patient outcomes.
Area of Science:
- Biomaterials Science
- Pulmonary Medicine
- Regenerative Medicine
Background:
- Persistent pulmonary air leaks prolong hospitalization.
- Existing hydrogel sealants lack elasticity and mechanical cohesion for lung tissue.
- Improved sealants are needed to address lung deformation and air leaks.
Purpose of the Study:
- To develop and evaluate an injury-conforming, dual-layer sealant for pulmonary air leaks.
- To assess the sealant's adhesive and cohesive strengths.
- To evaluate the sealant's compliance and efficacy in repairing air leaks in ventilated lungs.
Main Methods:
- Developed a dual-layer sealant with an adhesion layer and a bioprinted reinforcement layer.
- Conducted leak and rupture-pressure tests to evaluate sealant strength.
- Utilized computer vision-guided tracking to assess sealant-tissue compliance in ex vivo swine lungs during ventilation.
Main Results:
- The dual-layer sealant demonstrated significantly improved adhesive and cohesive strengths compared to single-layer controls.
- The sealant maintained structural integrity during cyclic ventilation, with a dynamic strain of 13.4% ± 0.8%.
- The sealant effectively repaired air leaks and restored peak-inspiratory pressure to baseline levels.
Conclusions:
- The developed dual-layer sealant effectively seals pulmonary air leaks.
- The sealant accommodates cyclic lung tissue deformation during ventilation.
- This technology shows promise for reducing hospitalization due to persistent air leaks.
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