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Updated: Aug 10, 2026

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Non-enzymatic colorimetric strategy for malathion detection based on Pt nanoparticles decorated porphyrin Zr
Qing Zhang1, Kuizhi Li1, Wanzhu Wang1
1College of Chemistry and Molecular Engineering, Jiangsu Provincial University Key Laboratory of Intelligent Medical Sensing Materials and Devices, Nanjing Tech University, Nanjing, 211800, China.
Abstract:
The presence of malathion (Mal) residues in food and water environment have garnered widespread public concern. Here, we developed PCN-224-supported Pt nanozymes through an in-situ reduction method, where the porous porphyrin framework and Pt sites jointly promote electron transfer and provide more active centers, leading to drastically enhanced oxidase (OXD)-mimicking activity. The obtained PCN-224@Pt can directly oxidize colorless TMB to blue oxTMB without H2O2, while the specific adsorption of Mal on the nanozyme surface will shield active sites and inhibit the catalytic reaction. Accordingly, a colorimetric sensor was then established to achieve sensitive determination of Mal in a linear detection range from 0.01 to 2.5 μg/mL with a low detection limit (LOD) of 6.62 ng/mL. Moreover, this platform displayed high selectivity and stability in food and water samples, with satisfactory recoveries of 90.1 %-107.7 % (RSDs < 9.31 %). This strategy provides a new attempt to construct nanozyme probes for direct detection of Mal, suitable for visual analysis in food and water environments.
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