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Gender-Specific Lipid Parameters Predict Excessive Daytime Sleepiness in Parkinson's Disease
Clinical Laboratory
|August 8, 2026
Summary
Excessive daytime sleepiness in Parkinson's disease (PD) is linked to lipid profiles in men but not women. Lipid metabolism disorders predict sleepiness in male PD patients, while motor and psychological factors are key in females.
Area of Science:
- Neuroscience
- Metabolic Disorders
- Sleep Medicine
Background:
- Lipid metabolism is crucial in neurodegenerative diseases like Parkinson's disease (PD).
- The connection between lipid profiles and excessive daytime sleepiness (EDS) in PD patients is not well understood.
- Investigating gender-specific relationships between lipid parameters and EDS is important for understanding PD pathophysiology.
Purpose of the Study:
- To explore the relationship between lipid parameters and EDS in PD patients.
- To identify potential gender differences in the factors contributing to EDS in PD.
- To determine if lipid profiles can serve as biomarkers for EDS in PD.
Main Methods:
- 176 PD patients were analyzed, categorizing them into PD with EDS (ESS ≥ 8) and PD without EDS (ESS < 8).
- Clinical data, including lipid profiles (total cholesterol, LDL-C, HDL-C), motor function scores (H-Y stage, UPDRS), and psychological scores (HAMD/HAMA), were collected.
- Statistical analyses included univariate and multivariate analyses, and receiver operating characteristic (ROC) analyses to identify predictive biomarkers.
Main Results:
- In male PD patients, elevated total cholesterol (TC) and reduced high-density lipoprotein cholesterol (HDL-C) were associated with EDS.
- TC/HDL-C ratio and non-HDL-C demonstrated high predictive ability for EDS in males (AUCs 0.745 and 0.691, respectively).
- No significant association was found between lipid parameters and EDS in female PD patients; motor and psychological factors were the primary predictors.
Conclusions:
- A significant gender disparity exists in the predictors of EDS among PD patients.
- Lipid metabolism disorders, particularly altered TC and HDL-C levels, are significant predictors of EDS in male PD patients.
- Motor dysfunction and psychological factors are the main contributors to EDS risk in female PD patients, highlighting the need for gender-specific management strategies.
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