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07:00

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Published on: February 26, 2019

Mechanism of action: Glucagon-like peptide-1 receptors in skin biology

Shilpa Mehta1

  • 1Division of Dermatology, Department of Medicine, John H Stroger Jr Hospital of Cook County, Chicago, Illinois, USA.

Clinics in Dermatology
|August 8, 2026
PubMed

Insights

Glucagon-like peptide-1 (GLP-1) receptors are present in skin cells, suggesting potential direct effects beyond diabetes treatment. This review explores evidence for GLP-1 receptor roles in skin physiology.

Area of Science:

  • Dermatology
  • Endocrinology
  • Molecular Biology

Background:

  • Glucagon-like peptide-1 (GLP-1) receptor agonists are established treatments for type 2 diabetes and obesity.
  • Emerging research indicates potential direct roles for GLP-1 in skin physiology, independent of metabolic effects.

Purpose of the Study:

  • To review and synthesize current evidence on the presence, distribution, and function of GLP-1 receptors in skin.
  • To evaluate the strength of evidence for GLP-1 receptor activity in various skin cell types and models.
  • To differentiate between direct cutaneous effects and indirect systemic effects of GLP-1.

Main Methods:

  • Systematic review of existing literature on GLP-1 receptors in skin.
  • Analysis of studies examining GLP-1 receptor expression (gene and protein) and function in keratinocytes, dermal fibroblasts, and endothelium.
  • Evaluation of evidence strength based on species, experimental models, and detection methods.

Main Results:

  • GLP-1 receptors are expressed in key skin cell types, including keratinocytes, fibroblasts, and vascular endothelium.
  • Evidence varies across species, cell culture, and human tissues, necessitating careful interpretation.
  • Distinction is made between direct GLP-1 receptor activation in skin and indirect effects via systemic metabolism or immune modulation.

Conclusions:

  • The presence and potential function of GLP-1 receptors in skin warrant further investigation.
  • GLP-1 may exert direct effects on skin health, opening new therapeutic avenues.
  • Future research should focus on clarifying the precise mechanisms and clinical relevance of GLP-1 signaling in the skin.

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