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AAV-delivered miRNA-gated Cre circuits enable programmable gene activation in AFP-active liver tumor models
Xiaoting Zhang1,2, Congcong Cao3,4, Zeqi Huang5
1Central Laboratory, Shenzhen Bao'an District Songgang People's Hospital, Shenzhen, China.
Researchers developed SLICER, a gene circuit using adeno-associated virus (AAV) vectors for precise tumor-selective gene activation. This system enhances safety by controlling therapeutic gene expression based on tumor markers and microRNAs, reducing off-target effects.
Area of Science:
- Oncology
- Gene Therapy
- Molecular Biology
Background:
- Selective gene activation in tumors is difficult due to promoter leakiness and intratumoral heterogeneity.
- Direct promoter-driven cytotoxic gene expression can compromise safety and specificity.
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