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Large Language Models as Health Information Tools: Patient Use and Trust in Otolaryngology
Beverly J Fu1, Itzel Rubio-Jimenez1, Alexander Ellman1
1Department of Otolaryngology-Head and Neck Surgery Stanford University School of Medicine Stanford California USA.
Laryngoscope Investigative Otolaryngology
|August 9, 2026
Summary
Large language model (LLM) use for health information is common in otolaryngology patients, offering perceived benefits despite moderate trust and accuracy concerns. Many patients found LLM information helpful and felt more prepared for appointments.
Area of Science:
- Medical Informatics
- Artificial Intelligence in Healthcare
- Patient-Reported Outcomes
Background:
- Patients increasingly utilize large language models (LLMs) for health information seeking.
- Understanding LLM usage patterns and their impact on otolaryngology patient care is limited.
Purpose of the Study:
- To characterize the use patterns, perceptions, and impact of LLMs on clinical communication among otolaryngology patients.
- To assess patient trust, perceived helpfulness, and preparedness after using LLMs for health information.
Main Methods:
- A cross-sectional survey was administered to adult patients at an academic otolaryngology clinic.
- The survey collected data on demographics, LLM use for general and health-related queries, and perceptions of LLM-generated information.
- Primary outcomes included overall LLM use for health information and pre-visit LLM usage.
Main Results:
- 71.2% of respondents reported prior LLM use, with 28.6% using LLMs for pre-visit information about their condition.
- LLM information was perceived as helpful by all participants and largely aligned with clinician explanations.
- Most patients felt more prepared for their visit, though trust in LLMs was moderate, with common concerns regarding accuracy and privacy.
Conclusions:
- LLM use for health information is prevalent among otolaryngology patients, associated with perceived benefits like improved preparedness.
- Despite moderate trust and accuracy concerns, factors such as accessibility and perceived empathy may drive LLM engagement.
- Most patients do not disclose LLM use to clinicians, highlighting a gap in communication.
