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A Modified Method for Heterotopic Mouse Heart Transplantion
Published on: June 23, 2014
Reuse of a Previously Transplanted Heart
Alexis Krin1,2, Myriam Addi3, Jean Porterie3
1Department of Anesthesia and Intensive Care, University Hospital of Toulouse, Toulouse, France, chu-toulouse.fr.
Case Reports in Transplantation
|August 9, 2026
Summary
This study reports the first cardiac graft reuse in France. A previously transplanted heart was successfully re-transplanted, offering a rare solution for donor organ shortages in heart failure treatment.
Area of Science:
- Cardiology
- Transplantation Medicine
- Surgical Innovation
Background:
- Heart transplantation is the optimal treatment for end-stage heart failure.
- A critical shortage of donor organs significantly limits heart transplantations globally.
- Graft reuse is an uncommon but viable strategy to expand the donor pool.
Purpose of the Study:
- To report the first case of cardiac graft reuse in France.
- To highlight the feasibility and outcomes of re-transplanting a previously used cardiac allograft.
- To contribute to the limited worldwide experience with cardiac graft reuse.
Main Methods:
- A 61-year-old male patient with end-stage dilated cardiomyopathy received a previously transplanted heart graft.
- The donor graft was obtained from a recipient who experienced brain death after their initial transplant.
- Pretransplant assessment confirmed the graft's preserved function before retransplantation.
Main Results:
- The patient underwent successful retransplantation with the previously used cardiac graft.
- Postoperative recovery was complicated by vasoplegic shock but ultimately showed a favorable course.
- At three-year follow-up, the patient maintained good functional status and preserved cardiac function.
Conclusions:
- Cardiac graft reuse is a feasible and potentially life-saving option for patients with end-stage heart failure facing donor organ scarcity.
- This case demonstrates the successful application of cardiac graft reuse in France, adding to global knowledge.
- Long-term follow-up indicates favorable outcomes, supporting the consideration of graft reuse in select cases.

