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Updated: Aug 10, 2026

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
Published on: October 17, 2025
When biological complexity demands more than better trial designs
Matteo Janni1, Celeste Cagnazzo1
1Azienda Ospedaliera Ospedale Infantile Regina Margherita - Sant'Anna, Torino, Italy.
Master protocols offer a flexible and sustainable approach to clinical research, enhancing evidence generation for precision medicine. These integrated frameworks address limitations of traditional randomized clinical trials (RCTs) in complex patient populations.
Area of Science:
- Clinical Research Methodology
- Precision Medicine
- Biostatistics
Background:
- Traditional randomized clinical trials (RCTs) face limitations with increasing precision medicine complexity, particularly in stratified populations and heterogeneous diseases.
- The need for more adaptive and efficient clinical trial designs is evident.
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