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Updated: Aug 11, 2026
06:46
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
Risk of Developing Subsequent Primary Colorectal Cancers Among Non-Colorectal Cancer Survivors: Implications for
Dylan E O'Sullivan1,2,3,4, Robert J Hilsden3,4,5, Hannah Harsanyi1
1Department of Cancer Epidemiology and Prevention Research, Cancer Care Alberta, Arthur Child Cancer Centre, Calgary, Alberta, Canada.
International Journal of Cancer
|August 10, 2026
Summary
Cancer survivors face a higher risk of developing subsequent colorectal cancer (CRC). Tailored screening is crucial for early detection and improved outcomes in this population.
Area of Science:
- Oncology
- Cancer Epidemiology
- Public Health
Background:
- Cancer survivors are at increased risk for new primary cancers.
- Colorectal cancer (CRC) is a significant concern for secondary cancer development.
Purpose of the Study:
- To investigate the incidence of CRC in cancer survivors compared to the general population.
- To identify risk factors and high-risk groups for subsequent CRC development.
Main Methods:
- Retrospective cohort study of 172,928 cancer survivors in Alberta, Canada (2000-2021).
- Comparison of CRC incidence rates using standardized incidence ratios (SIRs).
- Multivariable Fine-Gray models to identify risk factors.
Main Results:
- Cancer survivors showed an elevated risk of CRC (SIR = 1.26).
- Risk varied by first primary cancer site and persisted in both short- and long-term survivors.
- Survivors had higher risk of late-stage CRC, particularly in the proximal colon.
Conclusions:
- Cancer survivors require vigilant CRC screening due to elevated risk.
- Further research is needed to define enhanced screening strategies for high-risk survivor subgroups.
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