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REM Sleep Behavior Disorder Following Focal Brainstem Ischemia: A Case Series with Polysomnographic Characterization
Jiri Nepozitek1, Simona Dostalova1, Evzen Ruzicka1
1Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague 2, 128 21, The Czech Republic.
Nature and Science of Sleep
|August 10, 2026
Summary
Focal brainstem ischemia can cause Rapid Eye Movement (REM) sleep behavior disorder (RBD), characterized by dream-enacting behaviors. Polysomnography confirmed REM sleep without atonia (RWA) in two patients with ischemic brainstem lesions.
Area of Science:
- Neurology
- Sleep Medicine
- Neuroscience
Background:
- Rapid Eye Movement (REM) sleep behavior disorder (RBD) involves dream-enacting behaviors and REM sleep without atonia (RWA).
- RBD is often linked to synucleinopathies, but structural brainstem lesions as a cause are less documented.
- Focal brainstem lesions are a potential, though underreported, cause of secondary RBD.
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