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Chrysoeriol Alleviates Psoriasis Inflammation and Keratinocyte Hyperproliferation Possibly Through Inhibiting
Xiaoyue Qi1, Luoming Zhang2, Yaoxin Gao2
1School of Life Sciences, Zhengzhou University, Zhengzhou, 450052, People's Republic of China.
Journal of Inflammation Research
|August 10, 2026
Summary
Chrysoeriol (CHR) effectively treats psoriasis by reducing skin inflammation and normalizing immune cell activity. This natural compound suppresses abnormal skin cell growth and calms immune responses, offering a promising therapeutic option.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Psoriasis is a chronic inflammatory skin condition characterized by immune dysregulation and keratinocyte hyperproliferation.
- Current treatments can have significant side effects, driving the search for novel therapeutic agents.
- Chrysoeriol (CHR), a natural flavonoid, possesses known immunomodulatory and anti-inflammatory properties.
Purpose of the Study:
- To evaluate the anti-psoriatic efficacy of Chrysoeriol (CHR).
- To elucidate the underlying molecular mechanisms of CHR's action in psoriasis.
- To assess CHR's potential as a therapeutic candidate for psoriasis treatment.
Main Methods:
- Imiquimod (IMQ)-induced psoriasis-like mouse models and LPS-treated HaCaT cells were utilized.
- Anti-inflammatory effects were assessed via Psoriasis Area Severity Index (PASI) scoring, immunohistochemistry, immunofluorescence, and flow cytometry.
- Molecular mechanisms were investigated using transcriptome sequencing, immunoblotting, and qRT-PCR to analyze signaling pathways like AKT/NF-κB.
Main Results:
- Topical CHR application significantly reduced psoriatic symptoms in mice, including erythema, epidermal thickening, and scaling, correlating with improved PASI scores.
- CHR suppressed the over-activation of Th1/Th17 cells and inhibited keratinocyte hyperproliferation.
- CHR treatment led to decreased phosphorylation of AKT and p65, indicating modulation of the AKT/NF-κB signaling pathway.
Conclusions:
- Chrysoeriol (CHR) demonstrates significant anti-psoriatic effects by mitigating keratinocyte over-proliferation and restoring immune homeostasis.
- CHR effectively suppresses key inflammatory pathways, including the AKT/NF-κB signaling cascade.
- These findings highlight Chrysoeriol (CHR) as a potential natural therapeutic agent for managing psoriasis.
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