Perceived Competence and GLP-1RA Weight Management Engagement: Mixed-Methods Insights From Six Patient Groups

Area of Science:

• Endocrinology
• Behavioral Science
• Pharmacology

Background:

• Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are increasingly used for weight management.
• Understanding patient experiences is crucial for optimizing treatment outcomes.
• Perspectives vary across different stages of GLP-1RA therapy.

Purpose of the Study:

• To explore patient perspectives on GLP-1RAs for weight loss.
• To analyze experiences from initial consideration to discontinuation.
• To identify factors influencing patient engagement and goal achievement.

Main Methods:

• A mixed-methods approach using surveys and semi-structured interviews.
• Participants categorized into six groups based on therapy status and goal achievement.
• Qualitative and quantitative analyses to identify key themes and differences.

Main Results:

• Heterogeneity in psychosocial and behavioral profiles observed among participants.
• Higher perceived competence, intrinsic motivation, and self-monitoring in groups with goal achievement.
• Perceived competence significantly differed between groups, particularly in early-stage vs. successful long-term users.

Conclusions:

• Patient experiences with GLP-1RAs for weight loss are diverse.
• Perceived competence is a key differentiator in patient engagement.
• Tailored behavioral support is essential for successful weight loss journeys with GLP-1RAs.