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Crystalline Lens Tilts Less With Higher Myopia in Children With Limited Age-Related Effect
Ruozhen Ruan1, Jian Cao1, Xuepei Li1
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
Translational Vision Science & Technology
|August 10, 2026
Summary
Children
Area of Science:
- Ophthalmology
- Pediatric Optometry
- Biomedical Optics
Background:
- Crystalline lens morphology influences refractive development.
- Understanding lens tilt and decentration is crucial for pediatric eye care.
Purpose of the Study:
- To evaluate crystalline lens tilt in children across various orientations.
- To correlate lens morphology with age and refractive error (spherical equivalent).
Main Methods:
- Cross-sectional study of 966 eyes from 493 children (5-15 years).
- Swept-source anterior segment optical coherence tomography used for lens biometrics.
- Analysis included lens tilt, decentration, radii, thickness, and diameter in 16 orientations.
Main Results:
- Lens tilt and decentration showed semi-periodic variations, predominantly temporal-inferior tilt with temporal decentration.
- Non-myopic eyes had significantly more curved lenses (higher LAR and LPR) than myopic eyes.
- Lens tilt decreased with increasing myopia, showing a strong positive correlation with spherical equivalent within -4.18 D to +3.00 D.
Conclusions:
- Children's lenses exhibit a temporal-inferior tilt, becoming more orthotopic with higher myopia.
- Lens tilt is a less age-dependent biomarker for predicting myopia progression in children.
