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Longer arms, higher reactivity: equatorial coordination ring expansion boosts iron-oxo activity
Payal Panwar1, Jagnyesh K Satpathy1, Jason Z He2,3
1Department of Chemistry, Indian Institute of Technology Guwahati, Assam, 781039, India. sastricv@iitg.ac.in.
Chemical Communications (Cambridge, England)
|August 10, 2026
Summary
Equatorial sulfur coordination enhances enzymatic reactivity. A new ligand design significantly speeds up oxygen atom transfer, showing the importance of sulfur
Area of Science:
- Bioinorganic Chemistry
- Organometallic Chemistry
- Enzymatic Catalysis
Background:
- Equatorial sulfur coordination is crucial for enzymatic activity.
- Understanding sulfur's role can lead to improved catalysts.
Purpose of the Study:
- To investigate the impact of equatorial sulfur coordination on enzymatic reactivity.
- To synthesize and study novel N4S-bound pentadentate ligands.
Main Methods:
- Synthesis of two N4S-bound pentadentate ligands with varying scaffold structures.
- Evaluation of ligand performance in oxygen atom transfer reactions.
Main Results:
- A dramatic rate enhancement was observed for oxygen atom transfer.
- The enhancement is attributed to an increased redox potential facilitated by the ligand.
Conclusions:
- The ligand scaffold design significantly influences enzymatic reactivity.
- Equatorial sulfur coordination plays a key role in accelerating oxygen atom transfer reactions.
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