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Hyaluronic Acid Electrostatically Grafted Quaternary Ammonium Salt: Preparation and Outstanding Antibacterial
Yang Fu1, Mengli Wang2, Chao Geng1
1Laboratory of Polymer Materials Engineering, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin130022, P. R. of China.
Biomacromolecules
|August 10, 2026
Summary
New hyaluronic acid (HA)-based materials with grafted quaternary ammonium salts (QASs) show potent antibacterial activity against common wound pathogens. These advanced antibacterial dressings offer a promising antibiotic-free approach for wound infection treatment.
Area of Science:
- Biomaterials Science
- Infectious Diseases
- Polymer Chemistry
Background:
- Wound infections pose significant global health and economic challenges.
- Antibiotic resistance necessitates the development of alternative treatments like antibiotic-free medical dressings.
- Hyaluronic acid (HA) is a biocompatible polymer with potential for wound healing applications.
Purpose of the Study:
- To develop novel hyaluronic acid (HA)-based antibacterial materials.
- To investigate the efficacy of electrostatic grafting of quaternary ammonium salts (QASs) onto HA for antibacterial properties.
- To evaluate a HA-THA hydrogel as a potential medical dressing.
Main Methods:
- Fabrication of HA-based materials via electrostatic grafting of QASs onto HA.
- Assessment of antibacterial activity against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and Propionibacterium acnes (P. acnes) using minimum inhibitory concentrations (MICs).
- Construction of a HA-THA hydrogel using 1,4-butanediol diglycidyl ether (BDDE) as a cross-linker.
Main Results:
- Successfully synthesized HA-TPeAs and HA-THAs with significant antibacterial activity against E. coli and S. aureus (MICs of 0.25 and 0.004 mg/mL, respectively).
- Demonstrated potent inhibitory effects against P. acnes (MIC of 0.032 mg/mL).
- Developed a HA-THA hydrogel exhibiting strong antibacterial properties, good biocompatibility, and suitable mechanical characteristics.
Conclusions:
- Electrostatic grafting is an effective strategy for modifying HA with QASs to create antibacterial materials.
- The developed HA-THA hydrogel is a promising candidate for antibiotic-free medical antibacterial dressings.
- This approach addresses antibiotic resistance and promotes wound healing.
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