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Published on: June 11, 2019
Mitral Valve Malignant Glomus Tumor Presenting With Multiple Embolic Events
Miguel J Franquiz1, Aravind Krishnan2, Jesus R Lopez3
1Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA; Stanford Cardio-oncology Center, Cardiovascular Medicine, Stanford Hospitals and Clinics, Stanford, California, USA.
JACC. Case Reports
|August 10, 2026
Summary
Malignant cardiac glomus tumors are rare but can cause serious embolic events like stroke. Early diagnosis and multidisciplinary management, including surgical resection, are crucial for patients with these rare heart tumors.
Area of Science:
- Cardiovascular Pathology
- Oncology
- Surgical Case Reports
Background:
- Glomus tumors are rare mesenchymal neoplasms.
- Malignant glomus tumors are exceptionally rare.
- Cardiac involvement by glomus tumors is exceedingly uncommon.
Purpose of the Study:
- To report a rare case of malignant glomus tumor of the mitral valve.
- To highlight the embolic potential of intracardiac malignant glomus tumors.
- To emphasize the importance of a multidisciplinary approach in managing cardiac tumors.
Main Methods:
- Case report of a patient with a malignant mitral valve glomus tumor.
- Review of existing literature on intracardiac glomus tumors.
- Discussion of diagnostic and management strategies.
Main Results:
- The patient experienced recurrent arterial embolic events, including non-ST-segment elevation myocardial infarction and stroke.
- This represents the third reported case of an intracardiac malignant glomus tumor.
- The case underscores the diagnostic and therapeutic challenges posed by cardiac tumors.
Conclusions:
- Malignant glomus tumors of the heart are rare but carry significant embolic risk.
- Prompt evaluation by a multidisciplinary cardio-oncology team is essential.
- Surgical resection should be considered for cardiac glomus tumors.
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