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ASO Visual Abstract: Risk-adapted use of adjuvant systemic therapy after nephrectomy for renal cell carcinoma: a

Maximilian Filzmayer1,2, Michele Petix3,4,5, Leonardo Quarta3,6,7

  • 1Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, QC, Canada. filzmayer@med.uni-frankfurt.de.

Annals of Surgical Oncology
|August 10, 2026
PubMed
Abstract

No abstract available in PubMed .

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Renal Drug Clearance: Overview01:06

Renal Drug Clearance: Overview

Renal clearance is a crucial parameter in pharmacokinetics that quantifies the rate at which the kidneys excrete a drug. It represents a constant fraction of the central volume of distribution containing the drug that the kidney eliminates per unit of time.
Renal clearance can be calculated using different methods. One approach is to divide the urinary drug excretion rate by the plasma drug concentration. This method directly measures renal clearance, indicating the kidneys' efficiency in...