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Association of MIR30C rs928508 Polymorphism with Epidural Labor Analgesia Outcomes in Primiparous Women: An
Shilei Zhao1, Jiangtao Ma1, Xiaonan Zhang2
1Anaesthesiology Department, Shijiazhuang Sixth Hospital.
Genetic polymorphisms may influence individual variability in labor pain perception and analgesic efficacy. MicroRNA-30c (MIR30C) plays a role in pain modulation, but its association with labor analgesia remains unclear. This study investigated the association between the MIR30C rs928508 polymorphism and epidural labor analgesia in primiparous women. A total of 202 healthy Chinese Han primiparous women receiving standardized epidural analgesia with ropivacaine and sufentanil were enrolled. rs928508 genotypes (GG, GA, and AA) were detected using TaqMan assays, and Hardy-Weinberg equilibrium analysis was performed to assess population genetic distribution. Pain intensity was assessed using the Visual Analogue Scale (VAS) at baseline before analgesia, 30 min after analgesia, 1 h after analgesia, and after discontinuation of analgesia. Factors influencing labor analgesia outcomes were evaluated using multivariable regression analysis. Carriers of the GG genotype exhibited significantly higher VAS scores before analgesia, at 30 min after analgesia, and after discontinuation of analgesia, along with prolonged first-stage labor duration compared with GA and AA carriers. Multivariable regression analysis identified the GG genotype as an independent factor associated with higher post-analgesia VAS scores. Neonatal outcomes and most adverse reactions were comparable among genotypes, except for a higher incidence of puncture-site pain in GG carriers. The MIR30C rs928508 G allele was associated with increased baseline pain, potentially reduced epidural labor analgesia efficacy, and prolonged first-stage labor duration in primiparous women. These findings support further investigation into the potential pharmacogenomic relevance of MIR30C genetic variation in labor analgesia.
Genetic polymorphisms may influence individual variability in labor pain perception and analgesic efficacy. MicroRNA-30c (MIR30C) plays a role in pain modulation, but its association with labor analgesia remains unclear. This study investigated the association between the MIR30C rs928508 polymorphism and epidural labor analgesia in primiparous women. A total of 202 healthy Chinese Han primiparous women receiving standardized epidural analgesia with ropivacaine and sufentanil were enrolled. rs928508 genotypes (GG, GA, and AA) were detected using TaqMan assays, and Hardy-Weinberg equilibrium analysis was performed to assess population genetic distribution. Pain intensity was assessed using the Visual Analogue Scale (VAS) at baseline before analgesia, 30 min after analgesia, 1 h after analgesia, and after discontinuation of analgesia. Factors influencing labor analgesia outcomes were evaluated using multivariable regression analysis. Carriers of the GG genotype exhibited significantly higher VAS scores before analgesia, at 30 min after analgesia, and after discontinuation of analgesia, along with prolonged first-stage labor duration compared with GA and AA carriers. Multivariable regression analysis identified the GG genotype as an independent factor associated with higher post-analgesia VAS scores. Neonatal outcomes and most adverse reactions were comparable among genotypes, except for a higher incidence of puncture-site pain in GG carriers. The MIR30C rs928508 G allele was associated with increased baseline pain, potentially reduced epidural labor analgesia efficacy, and prolonged first-stage labor duration in primiparous women. These findings support further investigation into the potential pharmacogenomic relevance of MIR30C genetic variation in labor analgesia.
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