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The inhibitory receptor CD200R educates ILC1s for optimal cytotoxicity

Yawen Chen1, Zhengfeng Zhang1, Xianwei Wang1

  • 1State Key Laboratory of Immune Response and Immunotherapy, The Institute of Immunology, Biomedical Sciences and Health Laboratory of Anhui Province, Center for Advanced Interdisciplinary Science and Biomedicine of Institute of Health and Medicine, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.

Proceedings of the National Academy of Sciences of the United States of America
|August 10, 2026
PubMed
Summary

The inhibitory receptor CD200R educates type 1 innate lymphoid cells (ILC1s) for cytotoxicity, similar to natural killer (NK) cell education. This process enhances ILC1 cytotoxic competence but is not essential for IFN-γ production.

Keywords:
CD200RILC1scytotoxicityeducation

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