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Unraveling Time-Varying Effects of Risk Factors for Contralateral Invasive Breast Cancer Following Ductal Carcinoma
Yixin Guo1, Yongfang Xiao2, Ziqian Song3
1Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, China.
Clinical Breast Cancer
|August 10, 2026
Summary
Factors like race, age, and endocrine therapy influence contralateral invasive breast cancer (CIBC) risk after ductal carcinoma in situ (DCIS) over time. This understanding can help prevent overtreatment in DCIS patients.
Area of Science:
- Oncology
- Breast Cancer Research
- Epidemiology
Background:
- Contralateral invasive breast cancer (CIBC) risk following ductal carcinoma in situ (DCIS) is not fully understood.
- Existing studies lack consensus on influencing factors and their temporal variations.
Purpose of the Study:
- To investigate the time-varying effects of various factors on CIBC development after DCIS.
- To identify key predictors of CIBC risk in a large patient cohort.
- To inform strategies for reducing overtreatment in DCIS cases.
Main Methods:
- Utilized the Surveillance, Epidemiology, and End Results (SEER) database for 121,529 women diagnosed with DCIS (2000-2020).
- Employed time-dependent Cox models and landmark analysis with competing risks to assess time-varying effects.
- Analyzed annual incidence rates to illustrate temporal trends.
Main Results:
- Black patients exhibited a higher CIBC risk than White patients, particularly in mid-term follow-up.
- Older patients had higher early CIBC risk, decreasing over time due to mortality.
- Micropapillary subtype was linked to higher early CIBC risk; endocrine therapy showed a protective effect diminishing after ~10.6 years.
Conclusions:
- Race, age at diagnosis, and endocrine therapy significantly impact CIBC risk over time post-DCIS.
- These time-varying effects are crucial for personalized risk assessment and treatment decisions.
- Findings may aid in reducing overtreatment for ductal carcinoma in situ patients.
