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SWAM Mechanical Thrombectomy System versus AngioJet Rheolytic Thrombectomy System for Acute Lower Extremity Deep Vein
Hailong Zou1, You Zhao1, Zhongjie Ji2
1Department of Vascular Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Annals of Vascular Surgery
|August 10, 2026
Summary
The Zhongtian SWAM system offers comparable deep vein thrombosis clearance to AngioJet but with reduced procedure time, less thrombolytic use, and lower pulmonary embolism risk.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Medical Device Technology
Background:
- Acute lower extremity deep vein thrombosis (DVT) presents significant risks, including post-thrombotic syndrome and pulmonary embolism.
- Existing AngioJet rheolytic thrombectomy has limitations like hemolysis and embolic events.
- The Zhongtian SWAM system is a novel mechanical thrombectomy device designed to mitigate these risks.
Purpose of the Study:
- To compare the efficacy and safety of the Zhongtian SWAM system against the AngioJet system for acute lower extremity DVT.
- To evaluate thrombus clearance, procedural efficiency, and complication rates in a prospective, randomized trial.
Main Methods:
- A prospective, randomized trial involving 290 patients with acute lower extremity DVT (symptom duration ≤14 days).
- Patients were randomized 1:1 to either the SWAM system or the AngioJet system.
- Primary endpoint was thrombus clearance grade; secondary endpoints included procedural time, urokinase dose, PE incidence, plasma-free hemoglobin (PfHgb), and 6-month patency.
Main Results:
- Comparable Grade III thrombus clearance (78.6% SWAM vs. 72.4% AngioJet, P=0.221).
- Significantly shorter procedural time (42.3 min SWAM vs. 58.6 min AngioJet, P<0.001) and reduced urokinase use (150,000 IU SWAM vs. 350,000 IU AngioJet, P<0.001).
- Lower symptomatic PE incidence (1.4% SWAM vs. 5.5% AngioJet, P=0.048) and markedly reduced hemolysis (PfHgb 112.4 mg/dL SWAM vs. 438.7 mg/dL AngioJet, P<0.001).
Conclusions:
- The Zhongtian SWAM system demonstrates comparable thrombus clearance to AngioJet.
- SWAM offers significant advantages including shorter procedure times, reduced thrombolytic agent requirements, and a better safety profile with lower PE incidence and hemolysis.
- SWAM presents a safe and effective alternative for percutaneous mechanical thrombectomy in acute lower extremity DVT.