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A new phase in KRAS signaling

Krista A Budinich1, Liling Wan2

  • 1Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Trends in Cancer
|August 10, 2026
PubMed
Summary

Kirsten rat sarcoma virus oncogene homolog (KRAS) farnesylation drives cytoplasmic condensates, promoting KRAS processing, trafficking, and signaling. This discovery reveals condensate formation as a novel mechanism for regulating RAS activity.

Keywords:
KRASbiomolecular condensatescancerfarnesylationphase separation

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