Menopause and neurological disorders: a roadmap for research

Area of Science:

• Neuroscience
• Women's Health
• Menopause Research

Background:

• Menopause is an under-recognized factor influencing brain health.
• Limited scientific understanding exists regarding the menopausal transition's effect on the brain.
• This knowledge gap particularly affects women with existing neurological conditions.

Purpose of the Study:

• To identify research limitations and challenges in understanding menopause and brain health.
• To propose priorities and future research directions.
• To advance the understanding of the relationship between menopause and neurological health and disease.

Main Methods:

• Literature review and synthesis of existing knowledge.
• Identification of historical and scientific challenges hindering progress.
• Proposal of research priorities and future directions.

Main Results:

• Significant knowledge gaps exist concerning menopause's impact on neurological conditions.
• Two-thirds of women report cognitive concerns during the menopausal transition.
• The influence of the menopausal transition on the subsequent risk of neurological conditions is unclear.

Conclusions:

• Menopause is a critical biological and sociocultural factor for brain health.
• Further research is essential for sex-specific management of neurological conditions during and after menopause.
• Addressing research gaps will improve understanding and management of neurological health in menopausal women.