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From Structure to Function: Dibenzofuran Scaffold as a Versatile Platform for Diverse Biological Applications
Hojjat Rezaiezadeh1, Marziye Ranjbar Tavakoli2, Motahareh Sadeghzadeh2
1Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, P.O. Box 71345 Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran -1583, Shiraz, Iran.
Mini Reviews in Medicinal Chemistry
|August 11, 2026
Summary
Dibenzofuran (DBF) scaffolds are key in drug design, showing broad therapeutic effects like anti-cancer and anti-inflammatory activities. Further research into DBF derivatives can lead to new, improved medicines.
Area of Science:
- Medicinal Chemistry
- Pharmacology
- Drug Discovery
Background:
- The Dibenzofuran (DBF) scaffold is a crucial pharmacophore in many biologically active compounds.
- DBF derivatives exhibit a wide range of therapeutic activities, including antimicrobial, anticancer, and anti-inflammatory effects.
Purpose of the Study:
- To review and evaluate existing DBF derivatives, focusing on their bioactivities and mechanisms of action.
- To highlight the versatility of the DBF core in drug design and discovery.
Main Methods:
- Literature review and categorization of DBF derivatives.
- Analysis of Structure-Activity Relationships (SAR) to understand functional group influence.
- Evaluation of therapeutic potential and mechanisms of action.
Main Results:
- DBF-containing molecules demonstrate significant pharmacological potency and diverse therapeutic applications.
- SAR analyses provide insights into the molecular features driving the pharmacological diversity of DBF derivatives.
- The DBF core is identified as a versatile structural framework for developing novel therapeutics.
Conclusions:
- DBF scaffolds are essential in modern drug design due to their broad biological relevance.
- Further exploration via computational modeling and synthetic modifications is recommended to optimize DBF derivatives for improved efficacy and safety.
- DBF holds promise as a foundational element for future pharmaceutical research and development.