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Ostreae Concha Extract Mitigates Sleep Disturbances Through 5-HT and Vagus Nerve-Mediated Gut-Brain Axis Pathways

Feng Lu1, Qinyu Wang1, Qian Wang1

  • 1State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.

Current Pharmaceutical Design
|August 11, 2026
PubMed
Summary

Ostreae Concha (OC), derived from oyster shells, demonstrates sedative and hypnotic effects by enhancing serotonin (5-HT) and regulating the HPA axis. This traditional remedy offers a novel, sustainable approach to improving sleep quality.

Keywords:
5-HTGut-Brain AxisHPA axisInsomniaOstreae Concha

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