Related Experiment Video
Updated: Aug 12, 2026

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
Published on: January 12, 2018
The Relationship Between Neonatal and Maternal Factors and the Timing of Primary Tooth Eruption in Preterm Infants:
Ali Karimi Farani1, Mohammadamin Parsaei2, Ava Taghizadeh3
1School of Dentistry Tehran University of Medical Sciences Tehran Iran.
Insights
Preterm birth is linked to delayed primary tooth eruption. Breastfeeding and birth factors like gestational age influence eruption timing in premature infants.
Area of Science:
- Neonatal Health
- Pediatric Dentistry
- Developmental Biology
Background:
- Preterm birth is a known risk factor for delayed primary tooth eruption.
- Limited data exists on specific neonatal and maternal factors influencing this delay in premature infants.
Purpose of the Study:
- To investigate neonatal and maternal factors affecting the timing of the first primary tooth eruption in preterm infants.
- To identify predictors for both chronological and corrected age of tooth eruption.
Main Methods:
- Retrospective-prospective cohort study of 145 preterm neonates.
- Data collection included maternal comorbidities, birth details, and neonatal status.
- Weekly follow-up assessed tooth eruption and feeding; linear regression analyzed predictors.
Main Results:
- Higher gestational age, male sex, and larger head circumference predicted earlier chronological eruption.
- Lower gestational age, birthweight, and head circumference predicted earlier corrected-age eruption.
- Exclusive breastfeeding correlated with earlier chronological eruption.
Conclusions:
- Feeding status and anthropometric indices at birth are independent predictors of tooth eruption timing.
- Exclusive breastfeeding is associated with earlier chronological tooth eruption.
- Earlier corrected-age eruption in more premature infants may indicate compensatory growth.
Background And Aims:
Preterm birth is known to be associated with delayed primary tooth eruption, yet data on the factors influencing this delay in premature infants remain sparse. This study aims to investigate neonatal and maternal factors affecting the timing of the first primary tooth eruption.
Methods:
In this retrospective-prospective cohort study, medical records of 145 preterm neonates (85 males) admitted to the neonatal intensive care unit at a tertiary center in Iran (January-June 2024) were reviewed. Comprehensive data were collected on maternal comorbidities, birth details, and neonatal status. Weekly follow-up interviews assessed tooth eruption and feeding status. Linear regression analysis examined variables against eruption timing for both chronological and corrected age, with a significance level set at p < 0.05.
Results:
Median chronological eruption age was 8.0 [7.0, 10.0] months; mean corrected age was 6.5 ± 2.1 months. For chronological age, male sex (p = 0.015), higher gestational age (p = 0.001), and larger head circumference (p = 0.025) predicted earlier eruption, while higher magnesium delayed it (p = 0.045). For corrected age, lower gestational age at birth (p < 0.001), birthweight (p = 0.001), and head circumference (p = 0.002) were predictors of earlier eruption. Multivariate analysis showed that higher breastfeeding predicted earlier chronological eruption (p = 0.043), while lower gestational age at birth (p < 0.001), birthweight (p = 0.012), and head circumference at birth (p = 0.010) predicted earlier corrected eruption.
Conclusion:
Feeding status and anthropometric indices at birth emerged as independent predictors of tooth eruption. Exclusive breastfeeding associated with earlier chronological eruption, while earlier corrected-age eruption in more premature infants may reflect compensatory accelerated growth.
Related Concept Videos
Development of the Oral Microbiota
Teeth
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
Development of Human Microbiota