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Published on: December 8, 2023
Achilles Tendinopathy: Comorbidity Profile and Incidence From the TriNetX Network
Haiyin Li1,2, David Ciufo1,2, Edward Schwarz1,2
1Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.
Medical Research Archives
|August 11, 2026
Summary
Achilles tendinopathy incidence peaks in midlife (50-54 years) and is linked to higher comorbidity. Incidence varied by race and sex, with a notable dip during 2020 and a rebound in 2024.
Area of Science:
- Epidemiology
- Orthopedics
- Public Health
Background:
- Limited contemporary data exists on Achilles tendinopathy incidence across diverse demographics.
- The comorbidity burden associated with Achilles tendinopathy is not fully understood.
Purpose of the Study:
- To determine Achilles tendinopathy epidemiology in a large US electronic health record network.
- To analyze age, sex, and race-specific incidence rates.
- To characterize baseline patient demographics and comorbidity.
Main Methods:
- Utilized ICD-10-CM codes for Achilles tendinopathy identification in the TriNetX network.
- Estimated annual incidence rates per 100,000 person-years from 2015-2024.
- Assessed sex- and race-stratified age-specific incidence in 2024.
Main Results:
- Achilles tendinopathy patients exhibited a higher comorbidity burden.
- Incidence peaked at ages 50-54 years, showing a bell-shaped distribution.
- Overall incidence decreased in 2020, then increased, with highest rates in White patients in 2024.
- Sex-specific incidence varied, with males affected at younger ages and females in midlife, showing race-dependent crossover points.
Conclusions:
- Achilles tendinopathy is associated with increased comorbidity and a midlife incidence peak.
- Incidence patterns showed fluctuations, including a 2020 decline and rebound, with distinct demographic variations.
- Findings offer benchmarks for risk stratification, prevention strategies, and etiological research.
