Shape-Engineered BaTiO₃ Receivers for Ultrasonic Powering of Modular Localized Peritumoral Therapies

Area of Science:

• Biomedical Engineering
• Materials Science
• Acoustics

Background:

• Wireless ultrasonic power transfer is crucial for implantable medical devices, especially for deep implantation.
• Acousto-Bioelectronics studies acoustic energy transduction within the body.
• Existing systems face challenges in reliable energy delivery for advanced therapies.

Purpose of the Study:

• To explore the combined piezoelectricity and flexoelectricity effects in a miniaturized ultrasonic receiver.
• To develop an integrated Acousto-Bioelectronics system for multimodal cancer therapy.
• To establish a wireless omnidirectional powering microsystem platform for implantable devices.

Main Methods:

• Utilized a miniaturized pentagonal pyramid-shaped barium titanate ultrasonic receiver.
• Investigated the coupling effect of piezoelectricity and flexoelectricity.
• Employed finite element analysis and experimental validation for optimization.
• Assembled twelve receivers into a dodecahedron for a microsystem platform.

Main Results:

• A single unit cell (18.11 mm³ volume) achieved an output power of 2.39 mW at 400 Ω impedance.
• The system successfully generated light (10.1 mW/cm²), oxygen (4.301 μmol/L/min), and electric fields (up to 3 V/cm).
• Demonstrated sufficient power for simultaneous multimodal therapeutic functions.

Conclusions:

• The developed Acousto-Bioelectronic system offers a viable solution for wireless power transfer in implantable devices.
• The multimodal output capabilities show significant potential for localized, targeted cancer therapy.
• This technology advances the field of implantable medical devices and therapeutic applications.