Preventing, identifying, and managing sepsis in the community: research and clinical priorities

Kristina E Rudd1, Adrienne G Randolph1, Derek C Angus1

  • 1Center for Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA (K E Rudd MD, Prof D C Angus MD); Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA (Prof A G Randolph MD); Department of Anaesthesia, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Pediatrics, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Anaesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany (Prof M Bauer MD); Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley MD); Palliative and Advanced Illness Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley); Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA (C F Chesley); Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA (M R Filbin MD); Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA (Prof G Jenq MD, H C Prescott MD); Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA (J A Kempker MD); Watson Institute for International and Public Affairs, Brown University, Providence, RI, USA (Prof A C Levine MD); Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA (Prof A C Levine); Department of Emergency Medicine, Wayne State University, Detroit, MI, USA (Prof P Levy MD); Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil (Prof F R Machado MD); Departments of Emergency Medicine, Anesthesia, and Epidemiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA (Prof N M Mohr MD); Sepsis Scout, San Francisco, CA, USA (R Quinn PhD); CytoVale, San Francisco, CA, USA (R Quinn); Intensive Care National Audit and Research Centre, London, UK (Prof K Rowan PhD); Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK (Prof K Rowan); Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK (Prof M Shankar-Hari PhD); Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada (F Sheikh MSc); Weissman School of Arts and Sciences, Baruch College, City University of New York, New York, NY, USA (P Sleboda PhD); Families Fighting Flu, Prospect, KY, USA (J S Teichman MD); Service of Immunology and Allergy, Center of Human Immunology Lausanne, Department of Medicine and Department of Laboratory Medicine and Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland (Prof T Calandra MD); VA Center for Clinical Management Research, Ann Arbor, MI, USA (H C Prescott).

The Lancet. Primary Care
|August 11, 2026
PubMed

Related Concept Videos

Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed.
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Asepsis01:28

Asepsis

The condition of being free from disease-causing living pathogens is asepsis. Aseptic techniques include a set of standard practices to achieve asepsis. An example is the regular environmental cleaning of all parts of the healthcare facility and hand hygiene at home before preparing or eating food. Medical and surgical asepsis in healthcare practice protects patients from harmful pathogens, minimizes the risk of contamination of susceptible sites, and reduces the risk of infection transmission.
Standard Precaution01:26

Standard Precaution

Standard precautions are the minimum infection control safeguards used while caring for all patients, irrespective of their disease condition. They help prevent the spread of common infectious microorganisms to healthcare workers, patients, and visitors in all healthcare settings.
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
Urine Studies II: Urine Culture and Sensitivity Test01:26

Urine Studies II: Urine Culture and Sensitivity Test

A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...