Related Experiment Video
Updated: Aug 12, 2026

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection
Published on: February 19, 2019
Hepatitis C Micro-Elimination in a Deprived Coastal Town: Lessons From Blackpool
Sarah E Blagden1,2,3, Emma L MacFarlane4, Dianne C Draper2
1Blackpool Researching Together (NIHR Blackpool Health Determinants Research Collaboration) Blackpool UK.
Blackpool drug and alcohol services achieved hepatitis C virus (HCV) micro-elimination by integrating testing. Injecting drug use was the primary factor linked to positive HCV tests, highlighting the need for sustained testing practices.
Area of Science:
- Public Health
- Infectious Disease Epidemiology
- Substance Abuse Treatment
Background:
- Blackpool faces high hepatitis C virus (HCV) rates, being England's most deprived area.
- Low HCV testing rates were identified within local drug and alcohol treatment services.
- A multi-stakeholder strategy was implemented to boost HCV testing uptake.
Purpose of the Study:
- To evaluate the effectiveness of an integrated HCV testing strategy in Blackpool's drug and alcohol services.
- To assess HCV testing and treatment outcomes against national micro-elimination targets.
- To identify factors associated with positive HCV test results among service users.
Main Methods:
- Rapid evaluation using the UK Health Security Agency's model.
- Analysis of individual-level data from adult drug and alcohol treatment services (April 2024 - July 2025).
- Descriptive statistics, hypothesis testing, and binary logistic regression were employed.
Main Results:
- Out of 1071 clients tested, 32 (3%) had active HCV infection.
- Over 90% of those testing positive initiated treatment.
- Injecting drug use was the sole independent factor associated with HCV infection, mediating substance type effects.
Conclusions:
- Blackpool's drug and alcohol services successfully met all HCV micro-elimination criteria.
- Sustaining integrated HCV testing into routine practice is crucial for long-term success.
- The study demonstrates a successful model for HCV elimination in vulnerable populations.
Related Concept Videos
Hepatitis
Drug Elimination: Non-Renal Routes
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
Hepatic Drug Excretion: Enterohepatic Cycling
Post-release drugs and metabolites can be reabsorbed into the body from the intestine. For conjugated metabolites like glucuronides, reabsorption requires enzymatic hydrolysis by intestinal microflora. This...
Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration
Enhanced Elimination of Poison
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
