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Breaking the Mold: A Rare Case of Invasive Colonic Aspergillosis Causing Toxic Megacolon and Perforation in a Patient

Katharine Hunter Cook1, Jordan Woodard2, Christina Leyson2

  • 1Department of Internal Medicine, University of Kentucky, Lexington, KY.

ACG Case Reports Journal
|August 11, 2026
PubMed

Insights

Invasive gastrointestinal aspergillosis, a rare fungal infection, can occur even in patients not severely immunocompromised. Early diagnosis and antifungal treatment are crucial for managing severe colitis unresponsive to standard therapies.

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Mycology

Background:

  • Invasive gastrointestinal aspergillosis is a rare condition, predominantly affecting immunocompromised individuals.
  • Fulminant colitis can present with severe symptoms, including toxic megacolon, necrosis, and perforation.
Keywords:
colonic aspergillosiscolonic perforationimmunocompetent hostinvasive aspergillosistoxic megacolon

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