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Updated: Aug 12, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
B‑cell activating factor gene polymorphisms rs9514828 and rs1041569 increase preeclampsia risk
Kosar Shirvani Baghbabouie1, Danial Jahantigh1, Forough Forghani2
1Department of Biology, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran.
Specific BAFF gene variations are linked to a higher risk of preeclampsia (PE) in Iranian women. These findings suggest BAFF polymorphisms could be useful biomarkers for assessing PE risk.
Area of Science:
- Genetics
- Obstetrics
- Immunology
Background:
- Preeclampsia (PE) is a significant pregnancy complication.
- Genetic factors are implicated in PE susceptibility.
- BAFF gene polymorphisms are potential candidates for investigation.
Purpose of the Study:
- To investigate the association between BAFF gene polymorphisms (rs1041569 and rs9514828) and preeclampsia susceptibility in an Iranian population.
- To explore the relationship between these polymorphisms and PE severity and onset timing.
Main Methods:
- A case-control study involving 560 pregnant women (280 PE, 280 controls) from Zahedan, Iran.
- Genotyping using PCR-RFLP.
- Statistical analysis with logistic regression to determine odds ratios (ORs) and 95% confidence intervals (CIs).
Main Results:
- The CT and TT genotypes of rs9514828 were associated with increased PE risk (OR=1.81, p=0.011; OR=2.13, p=0.002).
- The AT and TT genotypes of rs1041569 also showed increased PE risk (OR=1.48, p=0.033; OR=1.68, p=0.037).
- Haplotype analysis indicated protective effects for C-A and T-T haplotypes (OR=0.69, p=0.003 for both).
Conclusions:
- BAFF gene polymorphisms are significantly associated with preeclampsia susceptibility in the Iranian population.
- These polymorphisms may serve as potential biomarkers for preeclampsia risk assessment.
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