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Updated: Aug 12, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
07:59

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

Total Synthesis of ent-Kaurenoic Acid Diterpenoids Enabled by Distal Conformational Control in Photoredox Radical

Jinbo Duan1, Xiaoqian He2, Xingyue Qi1

  • 1State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, P. R. China.

Angewandte Chemie (International Ed. in English)
|August 11, 2026
PubMed

Keywords:
cyclizationdivergent synthesisradicalsterpenoidstotal synthesis

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The absorption of UV–visible light by conjugated systems causes the promotion of an electron from the ground state to the excited state. Consequently, photochemical electrocyclic reactions proceed via the excited-state HOMO rather than the ground-state HOMO. Since the ground- and excited-state HOMOs have different symmetries, the stereochemical outcome of electrocyclic reactions depends on the mode of activation; i.e., thermal or photochemical.
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