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Updated: Aug 12, 2026
08:07
Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
Published on: April 5, 2024
Cardiovascular Disease (CVD) Risk in Women With Endometriosis: A Comprehensive Meta-Analysis
Maneeth Mylavarapu1,2, Jeffry Samuel3, Ravitej Thandi4
1Department of Cardiology, Endeavor Health Northshore Cardiovascular Institute, Endeavor Health Glenbrook Hospital, Glenview, Illinois, USA.
Clinical Cardiology
|August 11, 2026
Summary
Women with endometriosis have a significantly higher risk of cardiovascular disease (CVD) and major adverse cardiovascular events (MACE). This study highlights endometriosis as a key sex-specific factor influencing cardiovascular risk.
Area of Science:
- Reproductive Health and Cardiology
- Women's Health Research
- Chronic Inflammatory Diseases
Background:
- Cardiovascular disease (CVD) is a leading global cause of death.
- Cardiovascular risk in women is often underestimated.
- Endometriosis, affecting 5-10% of reproductive-aged women, is a chronic inflammatory condition with unclear cardiovascular implications.
Purpose of the Study:
- To synthesize current evidence on the association between endometriosis and cardiovascular outcomes.
- To evaluate the risk of overall CVD, major adverse cardiovascular events (MACE), and specific ischemic events in women with endometriosis.
Main Methods:
- Systematic literature search adhering to PRISMA guidelines.
- Inclusion of studies comparing cardiovascular outcomes in women with and without endometriosis.
- Use of random-effects models to calculate risk ratios (RRs) and 95% confidence intervals (CIs) for primary and secondary outcomes.
Main Results:
- Women with endometriosis showed significantly higher risks of overall CVD (RR 1.21) and MACE (RR 1.23).
- Elevated risks were observed for ischemic heart disease (IHD) (RR 1.57), coronary artery disease (CAD) (RR 1.36), and angina/acute myocardial infarction (Angina-AMI) (RR 1.62).
- Moderate to high statistical heterogeneity was noted for most secondary outcomes, except for CAD.
Conclusions:
- Endometriosis is significantly linked to increased risks of overall CVD, MACE, and ischemic coronary events.
- Endometriosis should be considered a crucial sex-specific factor modifying cardiovascular risk.
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