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Updated: Aug 12, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Blood pressure Time in Target Range and Clinical Outcomes in Chronic Kidney Disease

M Rahman1, Z Chen2, M Dweekat1

  • 1Division of Nephrology and Hypertension, University Hospitals Cleveland Medical Center, Case Western Reserve University.

American Journal of Hypertension
|August 11, 2026
PubMed

Insights

Maintaining blood pressure (BP) within the target range is crucial for patients with chronic kidney disease (CKD). Lower BP time in target range over five years significantly increases risks for cardiovascular events, kidney outcomes, and mortality.

Area of Science:

  • Nephrology
  • Cardiology
  • Clinical Research

Background:

  • Chronic kidney disease (CKD) affects millions globally, necessitating research into managing associated risks.
  • Blood pressure (BP) control is a cornerstone of CKD management.
  • Understanding the impact of BP variability on clinical outcomes in CKD is critical.

Purpose of the Study:

  • To investigate the association between blood pressure (BP) time in target range and clinical outcomes in patients with chronic kidney disease (CKD).
  • To quantify the risk of cardiovascular events, kidney outcomes, and mortality based on BP control levels in CKD patients.

Main Methods:

  • Analysis of 1908 participants from the Chronic Renal Insufficiency Cohort study.
  • BP was measured at each visit for five years.
  • BP time in target range (<130/80 mmHg) was calculated as the percentage of visits and categorized (<25%, 25-75%, >75%).

Main Results:

  • 430 participants (22.5%) had BP in target range <25% of visits.
  • 909 participants (47.6%) had BP in target range 25-75% of visits.
  • 569 participants (29.8%) had BP in target range >75% of visits.
  • Lower BP time in target range (<25% and 25-75%) was associated with significantly higher risks of cardiovascular events, kidney outcomes, and all-cause mortality compared to >75% control.

Conclusions:

  • Reduced blood pressure time in target range over five years is linked to increased risks of adverse renal and cardiovascular outcomes in CKD patients.
  • This highlights the importance of sustained BP control for improving prognosis in chronic kidney disease.
Abstract

Keywords:
blood pressure controlcardiovascular diseasechronic kidney diseasemortalitythe CRIC studytime in target range

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