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Is D-Dimer Associated With Disease Severity and Contralateral Slip Risk in Slipped Capital Femoral Epiphysis?
Muhammed B Kurk1, Kutalmis Albayrak2, Abdurrahman Aydin3
1Department of Orthopaedics and Traumatology, Medical Park Maltepe Hospital.
Journal of Pediatric Orthopedics
|August 11, 2026
Summary
Elevated D-dimer levels in slipped capital femoral epiphysis (SCFE) correlate with disease severity and contralateral slip risk. D-dimer may aid in risk stratification for this hip condition.
Area of Science:
- Orthopedics
- Pediatric Orthopedics
- Biochemistry
Background:
- Slipped capital femoral epiphysis (SCFE) is a hip condition affecting adolescents.
- Understanding factors associated with SCFE severity and progression is crucial.
Purpose of the Study:
- Evaluate D-dimer levels in SCFE patients.
- Assess D-dimer's association with disease severity and contralateral slip.
- Determine D-dimer's contribution to predictive models for SCFE.
Main Methods:
- Retrospective cohort study of 25 unilateral SCFE patients.
- Analysis of clinical, laboratory (including D-dimer, CRP, NLR), and radiographic parameters.
- Logistic regression and ROC curve analysis to predict contralateral slip.
Main Results:
- SCFE patients showed significantly higher D-dimer levels than controls.
- D-dimer correlated positively with CRP and NLR, and negatively with MOBS and interhip angle difference.
- Higher D-dimer levels were linked to unstable and acute-on-chronic SCFE, and contralateral slip development.
Conclusions:
- D-dimer levels are associated with SCFE severity and contralateral slip risk.
- Incorporating D-dimer into predictive models may improve risk stratification.
- Findings suggest inflammatory and microvascular roles in SCFE pathogenesis.
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