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Effects of Motivational Interview-Based Cognitive Therapy in Patients With Schizophrenia: A Multicenter Randomized
Yan-Liang Chen1,2, Chieh-Yu Liu3, Chiu-Yueh Yang4
1College of Nursing, National Yang Ming Chiao Tung University, Taipei, Taiwan.
The Journal of Nursing Research : JNR
|August 11, 2026
Summary
Motivational Interview-based Cognitive Therapy (MIBCT) significantly improved medication adherence and reduced positive symptoms in schizophrenia patients. This therapy enhances insight and addresses treatment barriers, leading to better patient outcomes.
Area of Science:
- Psychiatry
- Clinical Psychology
- Mental Health Research
Background:
- Treatment nonadherence in schizophrenia spectrum disorder leads to increased relapse and rehospitalization.
- Diminished quality of life is a significant consequence of poor medication adherence in these patients.
Purpose of the Study:
- To investigate the impact of motivational interview-based cognitive therapy (MIBCT) on medication adherence.
- To assess the effects of MIBCT on insight into illness among schizophrenia patients.
- To evaluate the influence of MIBCT on the severity of psychotic symptoms.
Main Methods:
- A single-blind, multicenter randomized controlled trial involving 120 participants in Taiwan.
- Participants were assigned to either MIBCT (n=61) or routine care plus psychoeducation (n=59).
- Outcomes measured included medication adherence (MARS), insight (SAI), and psychotic symptoms (PANSS) at baseline, interim, and postintervention.
Main Results:
- MIBCT significantly improved medication adherence (MARS scores) compared to the control group (p<.001).
- Enhanced insight (SAI) was observed in the MIBCT group during interim analysis (B=1.85, p=.003) and postintervention (B=2.23, p=.001).
- Significant reductions in positive symptoms were noted in the MIBCT group at interim analysis (B=-2.52, p=.002) and postintervention (B=-1.85, p=.029).
Conclusions:
- MIBCT effectively improves medication adherence, illness insight, and positive symptoms in schizophrenia spectrum disorder.
- The therapy enhances intrinsic motivation and overcomes treatment barriers.
- Psychiatric nurses can utilize MIBCT to potentially improve patient outcomes.
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