Related Experiment Video
Updated: Aug 13, 2026

Manual Segmentation of the Human Choroid Plexus Using Brain MRI
Published on: December 15, 2023
Choroid plexus volume in pathology-confirmed Alzheimer's disease
Francis Fernandes1, Avyarthana Dey2, Andy Ma2
1Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute - St. Michael's Hospital, Toronto, Ontario, Canada; Institute of Medical Sciences, Temerty Faculty of Medicine - University of Toronto, Toronto, Ontario, Canada.
Introduction:
The choroid plexus (CP) increases in volume across the Alzheimer's disease (AD) continuum, suggesting its potential as a clearance-related biomarker. However, few studies have examined ante-mortem CP volume in relation to post-mortem AD pathology, the gold standard for diagnosis.
Methods:
Participants who had structural magnetic resonance imaging and post-mortem pathology, with an interval of ≤ 5 years between imaging and death, were examined. Normalized CP volume (NCPV) was semi-automatically segmented from the lateral ventricles and analyzed using Bayesian linear regression to estimate associations with cognitive impairment (CI), AD pathology, and relevant clinical/demographic data.
Results:
Intermediate and high levels of AD pathology and CI were associated with larger NCPV, whereas female sex was associated with lower NCPV. Subgroup analyses showed larger NCPV in individuals with greater CI despite comparable levels of AD pathology.
Discussion:
These findings link CP enlargement to neuropathologically confirmed AD burden and CI, supporting further investigation of CP structure and function in AD.
More Related Videos
12:50Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
Published on: April 14, 2014
06:45Microdissection and Whole Mount Scanning Electron Microscopy Visualization of Mouse Choroid Plexus
Published on: December 16, 2022
Related Concept Videos
Alzheimer Disease ll: Pathophysiology
Cerebral Edema ll: Pathophysiology
Increased Intracranial Pressure ll: Pathophysiology
Dementia l: Introduction
Alzheimer Disease l: Introduction