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Published on: April 11, 2014
Energy-normalized ascorbic acid sono-dosimetry for assessing cavitation-derived oxidative activity
Oualid Hamdaoui1, Intissar Gasmi2, Muthupandian Ashokkumar3
1Chemical Engineering Department, College of Engineering, King Saud University, 12372 Riyadh, Saudi Arabia.
Ultrasonics Sonochemistry
|August 11, 2026
Summary
A new UV-Vis method uses ascorbic acid (AscA) to measure oxidative activity from ultrasound cavitation. This sonochemical dosimetry is simple, reproducible, and energy-normalized for comparing acoustic cavitation systems.
Area of Science:
- Physical Chemistry
- Chemical Kinetics
- Sonochemistry
Background:
- Ultrasound-induced acoustic cavitation generates reactive oxygen species.
- Quantifying cavitation-derived oxidative activity is crucial for understanding sonochemical processes.
- Existing methods may lack simplicity, reproducibility, or energy normalization.
Purpose of the Study:
- To develop a UV-visible sonochemical dosimetry method using ascorbic acid (AscA) sono-oxidation.
- To assess cavitation-derived oxidative activity in aerated aqueous solutions.
- To provide a simple, reproducible, and energy-normalized platform for comparing sonochemical activity.
Main Methods:
- Developed a UV-Vis dosimetry method based on AscA sono-oxidation.
- Used AscA as a probe for hydroxyl-radical-initiated oxidation, stabilized with NaCl.
- Monitored AscA consumption at 262 nm in a sonoreactor across various frequencies (585, 860, 1140 kHz) and power intensities.
- Analyzed AscA depletion kinetics, pH dependence, and gas atmosphere effects.
Main Results:
- AscA depletion followed apparent zero-order kinetics, indicating oxidant generation governed the rate.
- The apparent zero-order rate constant increased with calorimetric intensity at 585 kHz.
- Oxidative response decreased with increasing frequency, shown by decreasing GAscA values.
- The sono-oxidation rate was invariant between pH 4.8 and 8.
- Dissolved O2 significantly enhanced oxygen-mediated sonochemical radical pathways.
Conclusions:
- The developed AscA sono-dosimetry method is a simple, reproducible, and energy-normalized tool.
- It effectively measures cavitation-derived oxidative activity and complements H2O2 formation measurements.
- This method is suitable for comparing sonochemical activity across different acoustic cavitation systems.
- The findings highlight the importance of dissolved oxygen in sonochemical radical pathways.
