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Updated Models of Adolescent Substance-related Interference and Problems (A-SIP) and Measurement of Substance-related
Genevieve F Dash1, Kristine Rømer Thomsen2, Elisa M Trucco3
1Department of Psychiatry, UConn School of Medicine, Farmington, CT, USA; Department of Psychology and Behavioral Sciences, Center for Alcohol and Drug Research, Aarhus University, Aarhus C, Denmark.
Neuroscience and Biobehavioral Reviews
|August 11, 2026
Summary
Adolescent substance use models need updating to reflect brain development. A new definition, Adolescent Substance-related Interference and Problems (A-SIP), and a tool (SIP-IT) help clinicians identify issues in teens.
Area of Science:
- Neuroscience
- Clinical Psychology
- Developmental Psychology
Background:
- Adolescent and adult brains differ significantly in structure, connectivity, and function.
- Current etiological models, diagnostic systems, and assessments for adolescent substance use often overlook these neurodevelopmental distinctions.
- Translational research integrating adolescent brain science and clinical intervention is crucial for improving care.
Purpose of the Study:
- To evaluate current addiction and substance use disorder models for their developmental synchrony with adolescents.
- To propose a novel, developmentally-tailored definition and assessment for substance-related problems in adolescents.
- To address the gap between neurodevelopmental research and clinical practice in adolescent substance use.
Main Methods:
- Review of over 15 years of human translational research on adolescent brain development and clinical interventions for substance use.
- Evaluation of existing etiological models and diagnostic criteria for substance use disorders.
- Development of a new conceptualization and measurement tool for adolescent substance-related problems.
Main Results:
- Current models of addiction and substance use disorder criteria are not fully synchronized with adolescent neurodevelopment.
- A novel definition, Adolescent Substance-related Interference and Problems (A-SIP), is proposed, encompassing ten developmentally-informed symptoms across occupational, social/peer, and family domains.
- The accompanying tool, Substance-related Interference and Problems Identification Test (SIP-IT), is introduced for practical clinical use.
Conclusions:
- Existing frameworks for understanding adolescent substance use require significant revision to incorporate neurodevelopmental differences.
- The A-SIP framework and SIP-IT tool offer a more accurate and age-appropriate method for identifying and assessing substance-related problems in adolescents.
- Implementing developmentally-tailored approaches is essential for effective clinical intervention and treatment of adolescent substance use.
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