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Updated: Aug 13, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
Fronto-striatal molecular convergence in eating and obsessive-compulsive disorders
1Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.
Abstract:
The shared features of compulsivity in eating disorders (EDs) and obsessive-compulsive disorder (OCD) may reflect common molecular pathogenic processes. In a recent study, Breen et al. used postmortem human brain tissue to investigate fronto-striatal transcriptomic alterations in ED and OCD, identifying systems-level molecular convergence centered on neuronal energetics and synaptic signaling.
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